diff --git a/Dockerfile b/Dockerfile
index 2c3f4374..6c6b5c28 100644
--- a/Dockerfile
+++ b/Dockerfile
@@ -7,12 +7,14 @@ COPY . /opt/mautrixtelegram
 RUN apk add --no-cache \
       python3-dev \
       py3-virtualenv \
+      py3-pillow \
+      py3-aiohttp \
+      py3-lxml \
+      py3-magic \
+      py3-numpy \
+      py3-asn1crypto \
+      py3-sqlalchemy \
       build-base \
-      zlib-dev \
-      jpeg-dev \
-      libxslt-dev \
-      libxml2-dev \
-      libmagic \
       ffmpeg \
       bash \
       ca-certificates \
@@ -21,9 +23,7 @@ RUN apk add --no-cache \
  && cd /opt/mautrixtelegram \
  && cp -r docker/root/* / \
  && rm docker -rf \
- && virtualenv -p /usr/bin/python3 .venv \
- && source .venv/bin/activate \
- && pip install -r requirements.txt -r optional-requirements.txt
+ && pip3 install -r requirements.txt -r optional-requirements.txt
 
 VOLUME /data
 
diff --git a/docker/root/etc/s6.d/mautrix-telegram/run b/docker/root/etc/s6.d/mautrix-telegram/run
index 33a4da27..c82315a1 100755
--- a/docker/root/etc/s6.d/mautrix-telegram/run
+++ b/docker/root/etc/s6.d/mautrix-telegram/run
@@ -8,7 +8,7 @@ function fixperms {
 
 # Go into env
 cd /opt/mautrixtelegram
-source .venv/bin/activate
+export FFMPEG_BINARY=/usr/bin/ffmpeg
 
 # Replace database path in alembic.ini
 sed -i "s#sqlite:///mautrix-telegram.db#sqlite:////data/mautrix-telegram.db#" alembic.ini
@@ -28,7 +28,7 @@ if [[ ! -f /data/config.yaml ]]; then
 fi
 
 if [[ ! -f /data/registration.yaml ]]; then
-	python -m mautrix_telegram -g -c /data/config.yaml -r /data/registration.yaml
+	python3 -m mautrix_telegram -g -c /data/config.yaml -r /data/registration.yaml
 	echo "Didn't find a registration file."
 	echo "Generated ode for you."
 	echo "Copy that over to synapses app service directory."
@@ -36,7 +36,5 @@ if [[ ! -f /data/registration.yaml ]]; then
 	exit
 fi
 
-export FFMPEG_BINARY=/usr/bin/ffmpeg
-
 fixperms
-exec su-exec ${UID}:${GID} python -m mautrix_telegram -c /data/config.yaml
+exec su-exec ${UID}:${GID} python3 -m mautrix_telegram -c /data/config.yaml